Executive Order 14355: Unlocking Cures for Pediatric Cancer With Artificial Intelligence

Summary

The order sets a policy of using artificial intelligence to prevent and treat pediatric cancer. It directs the MAHA Commission to find ways to accelerate AI-driven solutions at the Childhood Cancer Data Initiative, to increase investment from existing federal funds, and to encourage private sector use of advanced technologies. It also directs the Secretary of Health and Human Services to integrate AI into interoperability work and to finalize interoperability standards for patient data used with AI, while patients and parents control their health information.

Who it applies to

Directs federal bodies, namely the MAHA Commission, the Secretary of Health and Human Services, the Director of the Office of Management and Budget and the Director of the National Institutes of Health, to use AI in pediatric cancer research and care. It creates no rights enforceable against the United States.

Key points

• The MAHA Commission is to develop ways to use AI to improve diagnoses, treatments, cures and prevention strategies for pediatric cancer, starting with the Childhood Cancer Data Initiative.
• Research funding at National Cancer Institute-Designated Cancer Centers is to prioritize AI-ready data infrastructure, biomarker analysis and improved clinical trial design.
• The MAHA Commission is to identify strategies to increase investment from existing Federal funds and to encourage private sector use of AI.
• The Secretary is to work to finalize interoperability standards for patient data used with AI that enable safe and privacy-compliant exchanges.
• Implementation is subject to applicable law and the availability of appropriations.

Key dates

Signed / adopted

Sep 30, 2025

Published (official journal)

Oct 7, 2025